To what extent can limiting cold ischaemia/reperfusion injury prevent delayed graft function?
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چکیده
منابع مشابه
To what extent can limiting cold ischaemia/reperfusion injury prevent delayed graft function?
Renal injury may be caused by numerous factors, including ischaemia, toxins and autoimmune diseases. In recent years, chronic allograft nephropathy has become one of the main causes of late organ loss following transplantation. Several clinical and experimental studies have suggested that, in addition to alloantigen-dependent factors, several alloantigenindependent factors may be also involved ...
متن کاملDelayed Graft Function
Delayed graft function (DGF) is a common complication of renal transplantation. According to a clinical data analysis of 34,647 cases of cadaveric renal transplantation documented by the Renal Transplantation Registry of the United Network Sharing (UNOS), graft function did not recover instantly after transplantation and for ever in some cases; the 1-year rate of graft loss was up to 20% in cas...
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Prolonged hypothermic storage causes ischemia-reperfusion injury (IRI) in the renal graft, which is considered to contribute to the occurrence of the delayed graft function (DGF) and chronic graft failure. Strategies are required to protect the graft and to prolong renal graft survival. We demonstrated that xenon exposure to human proximal tubular cells (HK-2) led to activation of range of prot...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2001
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/16.10.1982